(양식 1)

【 고분자학회 학회상 포상 지원서 】

[표지]
공모분야	KOPTRI 고분자학술상
지원자 인적사항	성 명	한 글	이동윤		영 문	Dong Yun Lee
		한 자	李東玧
	소속기관	기관명	한양대학교
		부서명 (학과명)	생명공학과		직위/직급	교수
		주 소	서울특별시 성동구 왕십리로 222
업적요지	본 지원자는 10편의 대표논문들을 통해서, (1) 크론병/궤양성 대장염 등과 같은 만성 염증 질환, 당뇨/비만 조직의 염증 질환, 질병치료를 위해 이식된 장기/세포치료제에 대한 면역반응 등 체내에서의 면역/염증 반응 등을 조절할 수 있는 고분자 기반의 소재 기술 (ACS Nano 2025 IF 16.0; Bioactive Materials 2025, IF 20.3 ; Nature Communications 2024, IF 15.7; Bioactive Materials 2024, IF 20.3; Small 2023, IF 12.1; Biomaterials 2022, IF 12.9 ; Science Advance 2021, IF 12.5; Journal of the American Chemical Society 2020, IF 15.6), (2) 뇌종양 및 당뇨병 등 질병치료를 위한 소재 중심의 경구제형화 플랫폼 기술 (Nature Communications 2023, IF 15.7 ; Bioactive Materials 2022, IF 20.3) 등을 개발하였습니다. 또한, 2021년 교원창업 법인기업을 설립하고 투자유치 및 딥테크 팁스 등 국가과제 수행을 통해서 실제 환자들에게 적용할 수 있도록 사업화를 진행하고 있습니다.
상기와 같이 고분자학회 학회상 포상을 지원합니다. 2025. 08. 28. 기관명 : 한양대학교 직 위 : 교수 지원자 : 이동윤 (직인)

(양식 2)

1. 인적사항

가. 학력사항 (대학교 이상만 기재)

기 간	학 교 명	전공 및 학위, 지도교수
2000.03-2005.02	광주과학기술원	신소재공학, 박사, 변영로
1998.03-2000.02	한양대학교	뇌과학, 석사, 채영규/임혜원
1994.03-1998.02	한양대학교	생화학, 학사

나. 경력사항 (5개 이내 기재)

기 간	기관명(직위, 직책 등)
2009.03-현재	한양대학교 공과대학 생명공학과(조교수, 부교수, 교수)
2021.01-현재	일릭사파마텍(주) (CEO & Founder)
2023.11-현재	한국연구재단 ICT융합연구단 전문위원(RB)
2019.03-2020.06	미국 유타대학교 약학대학 겸직교수(adjunct professor)
2007.11-2009.02	미국 하버드 의과대학(박사후연구원)

다. 수상경력 (최근 3년 이내)

※ 정부 포상, 민간 포상 등 연구개발 업적 관련 수상경력 모두 기재

일 자	수 상 내 용	시 상 기 관
2025.05.02.	TERM 학술상	한국조직공학재생의학회
2024.05.03.	엑셀세라퓨틱스 학술상	한국조직공학재생의학회

2. 수상후보자 추천인단 명부

성 명	전 공 분 야	세부전공 분야	소 속	비고
안동준	고분자	화공생명공학	고려대학교	2025년 추천
강영종	고분자	고분자화학	한양대학교	2025년 추천
고원건	고분자	화학공학	연세대학교	2025년 추천

3. 대표논문의 연구업적 요약서

본 지원자의 대표논문 10편은 고분자 기반의 바이오 소재 기술로써, 질병의 진단 및 치료 개발 내용으로 요약할 수 있습니다. 본 지원자는 우유단백질을 기반으로 뇌종양 표적화 및 레이저에 의한 항암치료를 할 수 있는 소재 (Bioactive Materials 2022, IF 20.3), 란탄계 원소를 포함하는 업컨버젼(upconversion) 나노입자 소재 (Nature Communications 2023, IF 15.7) 등을 개발하여 뇌종양 치료 가능성을 제시하였습니다. 한편, 당뇨병 치료의 이상적인 치료법은 인슐린을 분비하는 췌장 장기/세포 이식이지만, 이식 후의 면역/염증 반응 등에 의해서 치료 효과가 장기간 지속되질 않습니다. 이를 해결하기 위해서, 우선 면역반응을 광학영상으로 이미징 분석가능한 췌장세포 표적 가능한 zwitterion 기반 소재 (Journal of the American Chemical Society 2020, IF 15.6)과 Piezoelectric effect를 이용한 고효율의 췌장세포 덩어리(clusster)를 빠르게 제조할 수 있는 시스템 (Bioactive Materials 2025, IF 20.3) 등을 개발하였습니다. 또한, 면역반응을 억제하기 위해서, 생체적합성 고분자 알지네이트 유도체 및 특이적 효소 반응에 기반으로한 CAGE 기술 (Science Advance 2021, IF 12.5), 세포 내부에서 염증인자의 분비를 억제하는 소재 (Biomaterials 2022, IF 12.9), 이식된 세포/장기에 지속적으로 산소를 생산하여 공급할 수 있는 바이오-잉크 소재 (Nature Communications 2024, IF 15.7) 등을 개발하였습니다. 한편, 면역/염증 반응 억제 연구의 범위를 최근 사회적 이슈가 되는 크론병/궤양성대장염 치료기술 개발로 확장하였고, 그 결과 대장 부위의 염증반응을 억제할 수 있는 먹는(경구형) 나노입자인 오로자임(Aurozyme)을 개발하였고 (Small 2023, IF 12.1), 고분자 기반의 약물 전달체인 장점막 흡착형 COS-GL 시스템 (ACS Nano 2025, IF 16.0)을 개발하였습니다.  더불어, 비만 조직에서 발생하는 염증반응 억제를 이용한 항비만치료(anti-obesity) 효능을 갖는 소재 (Bioactive Materials 2024, IF 18.0) 등을 개발하고 있습니다.

요약하면, 본 지원자는 10편의 대표논문들을 통해서, (1) 특정 질병을 치료를 위한 소재 중심의 경구제형화 플랫폼 기술, (2) 효율적으로 질병 등을 비침습적 방법으로 진단할 수 있는 플랫폼 기술, (3) 체내에서 일어나는 면역/염증 반응을 제어할 수 있는 소재 기술 등을 개발하였습니다. 이 중, 일부 아이템을 사업화하기 위해서 2021년 교원창업 법인기업을 직접 창업하여 실제 환자들에게 적용할 수 있는 기술의 사업화를 진행하고 있습니다.

감사합니다.

* 10편의 대표논문 (SCIE 등재지, IF2025 기준)

4. 연구개발 실적

(1) 업적 총괄 (단위:건)

논문	SCIE 등재 학술지				h-index
	제1저자	공동저자	교신저자	소계	Web of Science	Google Scholar	SCOPUS
	18	41	73	132	41	47
특허	국내		국외		기술이전	연구 보고서	저서
	등록		등록
	29		12		1	0	8

*h-index 증빙자료(화면캡처본) 제출.

(2) 대표논문 목록 (SCIE 등재지, IF2025 기준)

연번	제 목	발표지명	Impactor factor	발표 년도	역할 (저자)	저자수 (명)	피인용 횟수
1	Mucoadhesive and self-assembled chitosan oligosaccharide-glycyrrhizin nanoparticles as an oral nanotherapeutic for immune modulation and barrier restoration in inflammatory bowel disease	ACS Nano	16.0	2025	교신저자	9	0
2	Subaqueous acoustic pressure system based one day heterotypic pseudo-islet spheroid formation with adipose derived stem cells for graft survival-related function enhancement	Bioactive Materials	20.3	2025	교신저자	18	1
3	Hyper-Oxygenating Respiratoid Biosystem for Therapeutic Cell Transplantation	Nature Communications	15.7	2024	교신저자	5	3
4	Immunotherapy Targeting the Obese Adipose Tissue Microenvironment: Focus on non-communicable diseases	Bioactive Materials	20.3	2024	교신저자	7	1
5	Aurozyme: A Revolutionary Nanozyme in Colitis, Switching Peroxidase-Like Activity	Small	12.1	2023	교신저자	3	4
6	A local water molecular-heating strategy for near-infrared long-lifetime imaging-guided photothermal therapy of glioblastoma	Nature Communications	15.7	2023	교신저자	7	11
7	DAMP-modulating nanoparticle for successful pancreatic islet and stem cell transplantation	Biomaterials	12.9	2022	교신저자	10	2
8	Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor	Bioactive Materials	20.3	2022	교신저자	3	28
9	Novel Enzymatic Crosslinking-based Hydrogel Nanofilm Caging System on Pancreatic β-cell Spheroid for Long-term Blood Glucose Regulation	Science Advances	12.5	2021	교신저자	12	29
10	Multimodal imaging probe development for pancreatic b-cells: from fluorescence to PET	Journal of the American Chemical Society	15.6	2020	교신저자	23	26

*제목 및 저자를 확인할 수 있는 증빙자료 제출.

(3) 총괄연구업적 목록

□ 학술지 논문 – SCIE 등재지에 한함 (IF2025 기준)

연번	제 목	발표지명	Impactor factor	발표 년도	역할 (저자)	저자수 (명)	피인용횟수
1	Mucoadhesive and self-assembled chitosan oligosaccharide-glycyrrhizin nanoparticles as an oral nanotherapeutic for immune modulation and barrier restoration in inflammatory bowel disease	ACS Nano	16.0	2025	교신저자	9	0
2	Subaqueous acoustic pressure system based one day heterotypic pseudo-islet spheroid formation with adipose derived stem cells for graft survival-related function enhancement	Bioactive Materials	20.3	2025	교신저자	18	1
3	Smart Nanomaterials for Multimodal Theranostics and Tissue Regeneration	Coordination Chemistry Reviews	23.5	2025	공동저자	21	0
4	Development of Cultivated Fish Meat: Advances in Cellular Agriculture, Biomaterials, and Scaffolding Techniques	Trends in Food Science & Technology	15.4	2025	공동저자	17	0
5	Preparation of Highly Functional Spheroid of Endocrine Cells Based on Thermosensitive Glycol Chitosan	Tissue Engineering and Regenerative Medicine	4.1	2025	교신저자	4	0
6	Hyper-Oxygenating Respiratoid Biosystem for Therapeutic Cell Transplantation	Nature Communications	15.7	2024	교신저자	5	3
7	Hierarchical three-layered fibers for bioaerosol and CO2 capture, and antimicrobial performance	Applied Surface Science	8.7	2024	교신저자	4	3
8	Biocompatible and nondegradable microcapsules using an ethylamine-bridged EGCG dimer for successful therapeutic cell transplantation	Journal of Controlled Release	11.5	2024	교신저자	5	1
9	Immunotherapy Targeting the Obese Adipose Tissue Microenvironment: Focus on non-communicable diseases	Bioactive Materials	20.3	2024	교신저자	7	6
10	Enhancing the Therapeutic Efficacy of GLP-1 for Hyperglycemia Treatment: Overcoming Barriers of Oral Gene Therapy with Taurocholic Acid-Conjugated Protamine Sulfate and Calcium Phosphate	ACS Nanoscience Au	6.3	2024	공동저자	5	4
11	Chromophoric cerium oxide nanoparticle-loaded sucking disk-type strip sensor for optical measurement of glucose in tear fluid	Biomaterials Research	9.6	2023	교신저자	10	8
12	Aurozyme: A Revolutionary Nanozyme in Colitis, Switching Peroxidase-Like Activity	Small	12.1	2023	교신저자	3	23
13	Nanoarchitectured Conjugates Targeting Angiogenesis: Investigating Heparin-Taurocholate Acid Conjugates (LHT7) as an Advanced Anti-Angiogenic Therapy for Brain Tumor Treatment	Biomaterials Research	9.6	2023	교신저자	4	2
14	Photosensitizing deep-seated cancer cells with photoprotein-conjugated upconversion nanoparticles	Journal of Nanobiotechnology	12.6	2023	교신저자	9	10
15	Inhibition of DAMP actions in the tumoral microenvironment using lactoferrin-glycyrrhizin conjugate for glioblastoma therapy	Biomaterials Research	9.6	2023	교신저자	4	15
16	A local water molecular-heating strategy for near-infrared long-lifetime imaging-guided photothermal therapy of glioblastoma	Nature Communications	15.7	2023	교신저자	7	30
17	Gastrointestinally absorbable lactoferrin-heparin conjugate with anti-angiogenic activity for treatment of brain tumor	Journal of Controlled Release	11.5	2023	교신저자	3	18
18	Next-generation 3D Scaffolds for Nano-Based Chemotherapeutics Delivery and Cancer Treatment	Pharmaceutics	5.5	2022	공동저자	8	18
19	DAMP-modulating nanoparticle for successful pancreatic islet and stem cell transplantation	Biomaterials	12.9	2022	교신저자	10	7
20	Pore Size-Dependent Stereoscopic Hydrogels Enhance the Therapeutic Efficiency of Botulinum Toxin for the Treatment of Nerve-Related Diseases	ACS Applied Materials & Interfaces	8.2	2022	공동저자	5	3
21	Heme oxygenase-1 gene delivery for altering high mobility group box-1 protein in pancreatic islet	Journal of Controlled Release	11.5	2022	교신저자	5	1
22	Milk protein-shelled gold nanoparticles with gastrointestinally active absorption for aurotherapy to brain tumor	Bioactive Materials	20.3	2022	교신저자	3	39
23	A novel therapeutic strategy of multimodal nanoconjugates for state-of-the-art brain tumor phototherapy	Journal of Nanobiotechnology	12.6	2022	교신저자	4	41
24	Nanomedicine in Clinical Photodynamic Therapy for the Treatment of Brain Tumors	Biomedicines	3.9	2022	교신저자	2	29
25	Nanozyme-based colorimetric biosensor with a systemic quantification algorithm for noninvasive glucose monitoring	Theranostics	13.3	2022	교신저자	4	68
26	Anticancer Effect of Heparin–Taurocholate Conjugate on Orthotopically Induced Exocrine and Endocrine Pancreatic Cancer	Cancers	4.4	2021	교신저자	7	6
27	Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy	Cancers	4.4	2021	교신저자	3	22
28	Hepatic and Renal Cellular Cytotoxic Effects of Heparin-coated Superparamagnetic Iron Oxide Nanoparticles	Biomaterials Research	9.6	2021	교신저자	3	11
29	Smart Engineering Strategy of Gold Nanoparticles to Improve Intestinal Barrier Penetration	Journal of Industrial and Engineering Chemistry	6.0	2021	교신저자	2	12
30	Optical Assessment of Tear Glucose by Smart Biosensor based on Nanoparticle Embedded Contact Lens	Nano Letters	9.1	2021	교신저자	8	84
31	Novel Enzymatic Crosslinking-based Hydrogel Nanofilm Caging System on Pancreatic β-cell Spheroid for Long-term Blood Glucose Regulation	Science Advances	12.5	2021	교신저자	12	55
32	Plasmid DNA Nanoparticles for Nonviral Oral Gene Therapy	Nano Letters	9.1	2021	공동저자	8	21
33	Cerium Oxide Nanoparticle-Containing Colorimetric Contact Lenses for Noninvasively Monitoring Human Tear Glucose	ACS Applied Nano Materials	5.5	2021	교신저자	10	36
34	Oral Delivery of Parathyroid Hormone Using a Triple-Padlock Nanocarrier for Osteoporosis via an Enterohepatic Circulation Pathway	ACS Applied Materials & Interfaces	8.2	2021	공동저자	7	20
35	Tear Glucose Measurement by Reflectance Spectrum of a Nanoparticle Embedded contact lens	Scientific Reports	3.9	2020	공동저자	4	80
36	Multimodal imaging probe development for pancreatic b-cells: from fluorescence to PET	Journal of the American Chemical Society	15.6	2020	교신저자	23	36
37	Multi-layer surface modification of islets for magnetic resonance imaging using ferumoxytol	Biomaterials	12.9	2019	공동저자	14	7
38	Electrospinning Nanofibers for Therapeutics Delivery	Nanomaterials	4.3	2019	교신저자	6	288
39	Hydrogels with an embossed surface: An all-in-one platform for mass production and culture of human adipose-derived stem cell spheroids	Biomaterials	12.9	2019	공동저자	8	69
40	Inducing angiogenesis with the controlled release of nitric oxide from biodegradable and biocompatible co-polymeric nanoparticles	International Journal of Nanomedicine	6.5	2018	교신저자	7	45
41	Near-Infrared-Responsive Cancer Photothermal and Photodynamic Therapy Using Gold Nanoparticles	Polymers	4.9	2018	교신저자	2	282
42	Hemostatic Swabs Containing Polydopamine-like Catecholamine Chitosan-Catechol for Normal and Coagulopathic Animal Models	ACS Biomaterials Science & Engineering	5.5	2018	공동저자	8	65
43	Senotherapy for attenuation of cellular senescence in aging and organ implantation	Journal of Industrial and Engineering Chemistry	6.0	2018	교신저자	3	5
44	Cell surface-camouflaged graphene oxide immunosensor for identifying immune reactions	Journal of Industrial and Engineering Chemistry	6.0	2018	교신저자	3	3
45	Oral delivery of a therapeutic gene encoding glucagon-like peptide 1 to treat high fat diet-induced diabetes	Journal of Controlled Release	11.5	2017	교신저자	12	39
46	Gene delivery to pancreatic islets for effective transplantation in diabetic animal	Journal of Industrial and Engineering Chemistry	6.0	2017	교신저자	6	1
47	Facile Determination of Sodium Ion and Osmolarity in Artificial Tears by Sequential DNAzymes	Sensors	3.5	2017	교신저자	4	8
48	Enhancement of T2-weighted MR contrast using heparin for cell tracking in vivo	Journal of Industrial and Engineering Chemistry	6.0	2017	교신저자	4	3
49	MRI-sensitive contrast agent with anticoagulant activity for surface camouflage of transplanted pancreatic islets	Biomaterials	12.9	2017	교신저자	3	15
50	Enhanced Self-Renewal and Accelerated Differentiation of Human Fetal Neural Stem Cells Using Graphene Oxide Nanoparticles	Macromolecular Bioscience	4.1	2017	교신저자	8	32
51	PEGylated bilirubin nanoparticle as an anti-oxidative and anti-inflammatory demulcent in pancreatic islet xenotransplantation	Biomaterials	12.9	2017	교신저자	4	115
52	The anterior chamber of the eye as a site for pancreatic islet transplantation	Journal of Industrial and Engineering Chemistry	6.0	2017	교신저자	2	4
53	Immunomodulation of Cell-Penetrating Tat-metallothionein for Successful Outcome of Xenotransplanted Pancreatic Islet	Journal of Drug Targeting	3.9	2017	교신저자	4	9
54	Synergism of highly transducible adenovirus encoding heme oxygenase 1 gene and low-dose immunosuppressants for successful outcomes of xenotransplanted pancreatic islet	Journal of Industrial and Engineering Chemistry	6.0	2017	교신저자	7	2
55	HMGB1 modulation in pancreatic islets using a cell-permeable A-box fragment	Journal of Controlled Release	11.5	2017	교신저자	5	17
56	Development of fluorescence-conjugated islet-homing peptide using biopanning for targeted optical imaging of pancreatic islet	Journal of Industrial and Engineering Chemistry	6.0	2017	교신저자	5	6
57	Photothermal therapy with gold nanoparticles as an anticancer medication	Journal of Pharmaceutical Investigation	5.1	2017	교신저자	2	84
58	Antiangiogenic actions of heparin derivatives for cancer therapy	Macromolecular Research	3.4	2016	교신저자	2	21
59	Application of nanomaterials for imaging pancreatic islets	Macromolecular Research	3.4	2016	교신저자	2	4
60	Infusion of human bone marrow-derived mesenchymal stem cells alleviates autoimmune nephritis in a lupus model by suppressing follicular helper T cell development	Cell Transplantation	3.2	2016	공동저자	9	90
61	Encapsulation of pancreatic islet with HMGB1 fragment for attenuating inflammation	Biomaterials Research	9.6	2015	교신저자	3	28
62	Optical imaging, biodistribution and toxicity of orally administered quantum dots loaded heparin-deoxycholic acid	Macromolecular Research	3.4	2015	공동저자	7	16
63	Feasibility of islet magnetic resonance imaging using ferumoxytol in intraportal islet transplantation	Biomaterials	12.9	2015	교신저자	10	13
64	Spheroform: Therapeutic Spheroid‐Forming Nanotextured Surfaces Inspired by Desert Beetle Physosterna cribripes	Advanced Healthcare Materials	9.6	2015	교신저자	7	29
65	Local co-delivery of pancreatic islets and liposomal clodronate using injectable hydrogel to prevent acute immune reactions in a type 1 diabetes	Pharmaceutical Research	4.3	2014	공동저자	5	35
66	Photoluminescent Graphene Nanoparticles for Cancer Phototherapy and Imaging	ACS Applied Materials & Interfaces	8.2	2014	교신저자	5	115
67	Microchip-based engineering of super-pancreatic islets supported by adipose-derived stem cells	Biomaterials	12.9	2014	공동저자	7	83
68	Pancreas-like extracellular matrix scaffold for successful pancreatic islet transplantation	Macromolecular Research	3.4	2014	교신저자	2	5
69	Hypoxic resistance of hypodermically transplanted pancreatic islets by using cell-absorbable antioxidant Tat-metallothionein	Journal of Controlled Release	11.5	2013	교신저자	8	18
70	Hypoxia as a target for tissue specific gene therapy	Journal of Controlled Release	11.5	2013	주저자	3	86
71	Xenotransplantation of exendin-4 gene transduced pancreatic islets using multi-component (alginate, poly-L-lysine, and polyethylene glycol) microcapsules for the treatment of type 1 diabetes mellitus	Journal of Biomaterials Science-Polymer Edition	3.6	2013	공동저자	5	11
72	Microfluidics-generated pancreatic islet microfibers for enhanced immunoprotection	Biomaterials	12.9	2013	교신저자	7	137
73	Drug delivery systems for the treatment of ischemic stroke	Pharmaceutical Research	4.3	2013	공동저자	3	63
74	Mutual effect of subcutaneously transplanted human adipose-derived stem cells and pancreatic islets within fibrin gel	Biomaterials	12.9	2013	교신저자	8	55
75	In Vivo Biodistribution and Toxicology of Carboxylated Graphene Quantum Dots	ACS Nano	16.0	2013	공동저자	7	584
76	Layer-by-layer building up of heparin and glycol chitosan for rat pancreatic islet xenotransplantation to mouse	Macromolecular Research	3.4	2013	공동저자	4	7
77	Magnetic separation of encapsulated islet cells labeled with superparamagnetic iron oxide nano particles	Xenotransplantation	4.1	2013	공동저자	12	24
78	3D co-culturing model of primary pancreatic islets and hepatocytes in hybrid spheroid to overcome pancreatic cell shortage	Biomaterials	12.9	2013	공동저자	7	85
79	Effects of surface camouflaged islet transplantation on pathophysiological progression in a db/db type 2 diabetic mouse model	Biochemical and Biophysical Research Communications	2.2	2013	공동저자	6	11
80	Optimal formation of genetically modified and functional pancreatic islet spheroids by using hanging-drop strategy	Transplantation Proceedings	0.8	2013	교신저자	8	26
81	The effects of 8-arm-PEG-catechol/heparin shielding system and immunosuppressive drug, FK506 on the survival of intraportally allotransplanted islets	Biomaterials	12.9	2013	공동저자	7	44
82	Synergistic effect of surface modification with poly (ethylene glycol) and immunosuppressants on repetitive pancreatic islet transplantation into antecedently sensitized rat	Transplantation Proceedings	0.8	2013	교신저자	7	25
83	Near infra-red photoluminescent graphene nanoparticles greatly expand their use in noninvasive biomedical imaging	Chemical Communications	4.2	2013	공동저자	5	129
84	Bio-inspired catechol conjugation converts water-insoluble chitosan into a highly water-soluble, adhesive chitosan derivative for hydrogels and LbL assembly	Biomaterials Science	5.7	2013	공동저자	4	222
85	Optimization of pancreatic islet spheroid using various concave patterned-films	Macromolecular Research	3.4	2012	교신저자	9	7
86	Dexamethasone conjugation to polyamidoamine dendrimers G1 and G2 for enhanced transfection efficiency with an anti-inflammatory effect	Journal of Drug Targeting	3.9	2012	공동저자	8	20
87	Molecularly Engineered Islet Cell Clusters for Diabetes Mellitus Treatment	Cell Transplantation	3.2	2012	교신저자	12	13
88	Magnetic resonance imaging using heparin-coated superparamagnetic iron oxide nanoparticles for cell tracking in vivo	Quantitative Imaging in Medicine and Surgery	2.3	2012	교신저자	2	21
89	Heparin-coated Superparamagnetic iron oxide for in vivo MR imaging of human MSCs	Biomaterials	12.9	2012	교신저자	7	83
90	Functional enhancement of beta cells in transplanted pancreatic islets by secretion signal peptide-linked exendin-4 gene transduction	Journal of Controlled Release	11.5	2012	교신저자	8	19
91	Amphiphilic peptides with arginine and valine residues as siRNA carriers	Journal of Cellular Biochemistry	2.8	2012	공동저자	5	25
92	In situ formation and collagen-alginate composite encapsulation of pancreatic islet spheroids	Biomaterials	12.9	2012	교신저자	7	140
93	Surface modification of pancreatic islets using heparin-DOPA conjugate and anti-CD154 mAb for the prolonged survival of intrahepatic transplanted islets in a xenograft model	Biomaterials	12.9	2012	교신저자	10	60
94	The box a domain of high mobility group box‐1 protein as an efficient siRNA carrier with anti‐inflammatory effects	Journal of Cellular Biochemistry	2.8	2012	공동저자	5	9
95	Fluorescently labeled nanoparticles enable the detection of stem cell-derived hepatocytes	Bulletin of the Korean Chemical Society	2.2	2012	공동저자	4	5
96	MRI of transplanted surface-labeled pancreatic islets with heparinized superparamagnetic iron oxide nanoparticles	Biomaterials	12.9	2011	교신저자	8	42
97	Functional Clustering of Pancreatic Islet Cells using concave microwell array	Macromolecular Research	3.4	2011	교신저자	8	25
98	Bio-inspired strategy for on-surface synthesis of silver nanoparticles for metal/organic hybrid nanomaterials and LDI-MS substrates	Bulletin of the Korean Chemical Society	2.2	2011	공동저자	8	77
99	Surface camouflage of pancreatic islets using 6-arm-PEG-catechol in combined therapy with tacrolimus and anti-CD154 monoclonal antibody for xenotransplantation	Biomaterials	12.9	2011	교신저자	13	64
100	Control of adhesion, focal adhesion assembly, and differentiation of myoblasts by enzymatically crosslinked cell-interactive hydrogels	Macromolecular Research	3.4	2011	공동저자	5	23
101	Islet Surface PEGylation Attenuate the Instant Blood-Mediated Inflammatory Reaction in Intrahepatic Islet Transplantation	Macromolecular Research	3.4	2011	교신저자	1	4
102	Highly Effective T2 MR Contrast Agent Based on Heparinized Superparamagnetic Iron Oxide Nanoparticles	Macromolecular Research	3.4	2011	교신저자	1	30
103	Physicochemical conjugation with Deoxycholic Acid and Dimethylsulfoxide for Heparin Oral Delivery	Bioconjugate Chemistry	3.9	2011	교신저자	6	26
104	Attenuation of the In Vivo Toxicity of Biomaterials by Polydopamine Surface Modification	Nanomedicine	3.9	2011	교신저자	7	335
105	Diabetes Correction in Pancreatectomized Canines by Orally Absorbable Insulin− Deoxycholate Complex	Molecular Pharmaceutics	4.5	2010	교신저자	5	28
106	Pancreatic islet PEGylation as an immunological polymeric restraint	Biotechnology and Bioprocess Engineering	3.0	2010	주저자	2	14
107	Antiangiogenic activity of orally absorbable heparin derivative in different types of cancer cells	Pharmaceutical Research	4.3	2009	주저자	8	24
108	Antimetastatic Effect of an Orally Active Heparin Derivative on Experimentally Induced Metastasis	Clinical Cancer Research	10.2	2008	주저자	7	55
109	Optimal aggregation of dissociated islet cells for functional islet-like cluster	Journal of Biomaterials Science-Polymer Edition	3.6	2008	주저자	4	12
110	A newly developed oral heparin derivative for deep vein thrombosis: non-human primate study	Journal of Controlled Release	11.5	2007	공동저자	6	32
111	Liphophilic Complexation of Heparin Based on Bile Acid for Oral Delivery	Journal of Controlled Release	11.5	2007	주저자	5	51
112	Highly poly (ethylene) glycolylated islets improve long-term islet allograft survival without immunosuppressive medication	Tissue Engineering	2.9	2007	주저자	5	73
113	Absorption study of deoxycholic acid-heparin conjugate as a new form of oral anti-coagulant	Journal of Controlled Release	11.5	2007	공동저자	6	70
114	Suppression of angiogenesis and tumor growth by orally active deoxycholic acid-heparin conjugate	Journal of Controlled Release	11.5	2007	주저자	9	58
115	Functional and histological evaluation of transplanted pancreatic islets immunoprotected by PEGylation and cyclosporine for 1 year	Biomaterials	12.9	2007	주저자	3	105
116	Antiangiogenic and apoptotic properties of a novel amphiphilic folate-heparin-lithocholate derivative having cellular internality for cancer therapy	Pharmaceutical Research	4.3	2007	주저자	12	65
117	The short-term effects on restenosis and thrombosis of echinomycin-eluting stents topcoated with a hydrophobic heparin-containing polymer	Biomaterials	12.9	2007	공동저자	6	56
118	Minimization of immunosuppressive therapy after islet transplantation: Combined action of heme oxygenase‐1 and PEGylation to islet	American Journal of Transplantation	8.2	2006	주저자	4	77
119	Pharmacokinetics of a new, orally available ceftriaxone formulation in physical complexation with a cationic analogue of bile acid in rats	Antimicrobial Agents and Chemotherapy	4.5	2006	공동저자	5	39
120	Efficacy of Orally Active Chemical Conjugate of Low Molecular Weight Heparin and Deoxycholic Acid in Rats, Mice and Monkeys	Journal of Controlled Release	11.5	2006	공동저자	8	66
121	A new strategy toward improving immunoprotection in cell therapy for diabetes mellitus: Long-functioning PEGylated islets in vivo	Tissue Engineering	2.9	2006	주저자	4	75
122	A combination therapy of PEGylation and immunosuppressive agent for successful islet transplantation	Journal of Controlled Release	11.5	2006	주저자	4	70
123	Prevention effect of orally active heparin derivative on deep vein thrombosis	Thrombosis and Haemostasis	4.3	2006	공동저자	5	16
124	Cationic analog of deoxycholate as an oral delivery carrier for ceftriaxone	Journal of Pharmaceutical Sciences	3.8	2005	주저자	7	38
125	Synthesis and Biological Properties of Insulin− Deoxycholic Acid Chemical Conjugates	Bioconjugate Chemistry	3.9	2005	공동저자	8	106
126	A new drug carrier, Nα-deoxycholyl-l-lysyl-methylester, for enhancing insulin absorption in the intestine	Diabetologia	10.2	2005	공동저자	6	55
127	Preparation and characterization of self-assembled nanoparticles of heparin-deoxycholic acid conjugates	Langmuir	3.9	2004	공동저자	7	189
128	Immune reactions of lymphocytes and macrophages against PEG-grafted pancreatic islets	Biomaterials	12.9	2004	주저자	4	133
129	Effect of polyethylene glycol grafted onto islet capsules on prevention of splenocyte and cytokine attacks	Journal of Biomaterials Science-Polymer Edition	3.6	2004	주저자	3	56
130	Optimization of monomethoxy-polyethylene glycol onto the pancreatic islet capsules	Journal of Biomedical Materials Research	3.9	2002	주저자	8	98
131	17beta-Estradiol inhibits high-voltage-activated calcium channel currents in rat sensory neurons via a non-genomic mechanism	Life Sciences	5.1	2002	주저자	7	105
132	Ginseng and ginsenoside Rg(3), a newly identified active ingredient of ginseng, modulate Ca2+ channel currents in rat sensory neurons	European Journal of Pharmacology	4.7	2002	공동저자	5	138

□ 등록된 국내외 특허

연번	제 목	등록번호	등록년도	등록국가	역할
1	신규한 서열의 펩타이드 및 글리시리진을 포함하는 접합체 및 이를 포함하는 비만의 예방 또는 치료용 약학적 조성물	10-2841921	2025	대한민국	교신
2	염증성 장질환 치료를 위한 경구형 항염증성 저분자 화합물 및 이의 용도	10-2730443	2024	대한민국	교신
3	Alginate microcapsule for cell encapsulation and, manufacturing method thereof	12,077,645	2024	USA	교신
4	Alginate microcapsule for cell encapsulation and, manufacturing method thereof	03782613	2023	EU	교신
5	用于细胞包膜的藻酸盐微胶囊及其制备方法	ZL201980024085.8	2023	CHINA	교신
6	甘草甜素-乙二醇壳聚糖共轭物包覆氧化铁纳米粒子及其用途	ZL201980023209.0	2023	CHINA	교신
7	Cell-encapsulated hydrogel block preparation for 3D bioprinting-based tissue engineering and macrostructure assembly technology thereof	11,602,581	2023	USA	교신
8	Lactoferrin-conjugated nanoparticle complex and use thereof	11,369,425	2022	USA	교신
9	細胞皮膜化用アルギン酸塩微細カプセル及びその製造方法	07162361	2022	JAPAN	교신
10	Lactoferrin-based oral gene carrier for treatment of Type 2 Diabetes Mellitus using gene therapy	11,471,540	2022	USA	교신
11	글리시리진-글리콜 키토산 중합체를 포함하는 비만치료용 조성물	10-2436124	2022	대한민국	교신
12	Pharmaceutical Compositions for Inhibiting Cell Transplant Rejection	11,191,808	2021	USA	교신
13	생체 내 이식 신경세포 추적 플랫폼	10-2315868	2021	대한민국	참여
14	RGB 값을 이용한 포도당 농도 측정 장치	10-2314687	2021	대한민국	교신
15	눈물 내 포도당 검출을 위한 세륨산화물 나노입자 기반의 발색형 콘택트렌즈 센서 개발	10-2265827	2021	대한민국	교신
16	염증성 장질환 예방 또는 치료용 생체적합성 고분자-글리시리진 컨쥬게이트	10-2249213	2021	대한민국	교신
17	3D바이오프린팅기반조직공학을위한세포-봉입한하이드로젤블록제작및이의거대구조체조립화기술	10-2204668	2021	대한민국	교신
18	글리시리진-글리콜 키토산 코팅된 산화철 나노입자 및 이의 용도	10-2199156	2020	대한민국	교신
19	Lactoferrin-conjugated nanoparticle complex and use thereof	10,828,083	2020	USA	교신
20	세포 피막화용 알지네이트 미세캡슐 및 이의 제조방법	10-2158730	2020	대한민국	교신
21	제2형 당뇨병의 유전자치료를 위한 락토페린 기반의 경구흡수형 유전자 전달체 개발	10-2144380	2020	대한민국	교신
22	종양 표적 치료용 락토페린-글리시리진 컨쥬게이트	10-2094255	2020	대한민국	교신
23	고생존율 및 고기능성 내분비 세포클러스터의 제조방법	10-2051525	2019	대한민국	교신
24	눈물 내 포도당 검출을 위한 세륨산화물 나노입자 기반의 발색형 콘택트렌즈 센서 개발	10-2039148	2019	대한민국	교신
25	췌장 소도 세포 표적 펩타이드 및 이의 용도	10-2006890	2019	대한민국	교신
26	락토페린-저분자량 헤파린 나노복합체 및 이의 용도	10-1938218	2019	대한민국	교신
27	락토페린이 결합된 나노입자 복합체 및 이의 용도	10-1925791	2018	대한민국	교신
28	핵산효소를 이용한 눈물 내 나트륨 이온을 검출하기 위한 조성물 및 이를 이용한 나트륨 이온 검출 방법	10-1919365	2018	대한민국	참여
29	췌도 세포 이식용 조성물	10-1761092	2017	대한민국	교신
30	경구 투여용 유전자 전달을 위한 나노입자 및 이를 포함하는 약학 조성물	10-1741977	2017	대한민국	교신
31	세포 이식 거부반응 억제용 약제학적 조성물	10-1689540	2016	대한민국	교신
32	형광공명에너지전이 현상을 이용한 면역반응 영상화	10-1552943	2015	대한민국	교신
33	이중기능성 고차구조의 PEG 및 생체활성 복합체를 이용한 췌장소도 표면개질 방법 및 이를 이용한 표면개질된 췌장소도	10-1436466	2014	대한민국	참여
34	이식용 마이크로파이버 및 그 제조방법	10-1366454	2014	대한민국	교신
35	오목 마이크로웰을 이용하는 내분비세포 배양방법	10-1289023	2013	대한민국	교신
36	제1형 당뇨병 치료를 위한 분비 신호 펩타이드가 연결된 엑센딘-4를 도입한 췌장소도세포 클러스터	10-1286689	2013	대한민국	참여
37	표면이 개질된 췌장소도 봉입용 캡슐 및 이의 제조방법	10-1220429	2013	대한민국	참여
38	생체적합성 매개 고분자와의 화학적 결합을 이용한 분자 영상화 시스템	10-1220158	2013	대한민국	교신
39	Surface Modification of Islet Membranes by Polymeric Grafting Method	US 20070207118	2007	USA	참여
40	Surface Modification of Islet Membranes by Polymeric Grafting Method	200111768	2002	AU	참여
41	고분자 결합을 이용한 췌장소도 막의 표면개질 방법	10-2002-0031893	2002	대한민국	참여

□ 프로그램 저작전 실적

연번	출판 년도	저작권명	등록국가	등록번호	역할
1	2020	렌즈 발색변화를 이용한 논물 당 측정	대한민국	C-2020-016628	교신

□ 기술이전 실적

연번	이전 년도	이전기술명	기술이전 기업	기술이전료	비고
1	2019	신경세포 분화 추적용 벡터 및 이를 이용한 신경세포로의 분화추적 방법	코아스템(주)	(한양대 지분 계약금) 19,000,000원	(총액) 11억3천만원

□ 저서 실적

연번	출판 년도	Book Title / Chapter	출판사	ISBN	역할
1	2025	Sustainable Biopolymers and Composites for Biomedical Applications / Chapter 12. Lignin as a Drug Encapsulant	Springer	978-3-031-91971-8	교신
2	2020	Advances in Experimental Medicine and Biology 1249: Bioinspired Biomaterials / Chapter 13. Protein-based drug delivery in brain tumor therapy	Springer	978-981-15-3257-3	교신
3	2018	Advances in Experimental Medicine and Biology 1064: Biomimetic Medical Materials : From Nanotechnology to 3D Bioprinting / Chapter 13. 3D Bioprinting for Artificial Pancreas Organ	Springer	978-981-13-0444-6	교신
4	2018	Advances in Experimental Medicine and Biology 1078: Cutting-Edge Enabling Technologies for Regenerative Medicine / Chapter 9. Materials and Applications of Smart Diagnostic Contact Lens Systems	Springer	978-981-13-0949-6	교신
5	2017	Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine (2nd Edition) / Chapter 27. “Intelligent scaffold-mediated enhancement of the viability and functionality of transplanted pancreatic islets to cure diabetes mellitus”	Pan Stanford Publishinig Pte. Ltd.	978-981-4745-12-3	교신
6	2016	Biomedical Engineering: Frontier Research and Converging Technologies / Chapter 2. “Nanoparticles for pancreatic islet imaging”	Springer	978-3-319-21812-0	교신
7	2013	Cancer Targeted Drug Delivery / Chapter 7. “Cancer Cell Respiration: Hypoxia and pH in Solid Tumors”	Springer	978-1-4614-7876-8	제1저자
8	2002	Tissue Engineering and Regenerative Medicine / Chapter 38. “Immunoisolation”	Kunja	89-7089-296-6	제1저자